Exposure towards the glucuronide metabolite is 35 to 40 instances greater than exposure for the mum or dad drug. In vitro knowledge counsel that hydromorphone in clinically pertinent concentrations has small likely to inhibit the activity of human hepatic CYP450 enzymes together with CYP1A2, 2C9, 2C19, 2D6, 3A4, and 4A11.Get emergency health care s